Influenzanet is a system to monitor the activity of influenza-like-illness (ILI) with the aid of volunteers via the internet

http://www.influenzanet.eu/

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Developing the framework for an epidemic forecast infrastructure.
http://www.epiwork.eu/

The Seventh Framework Programme (FP7) bundles all research-related EU initiatives.

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Participating countries and volunteers:

Participating countries and volunteers:

The Netherlands 10273
Belgium 3610
Portugal 1904
Italy 4160
Great Britain 2587
Sweden 6461
Austria 388
Switzerland 113
France 3663
Spain 983
Ireland 241
Denmark 921
InfluenzaNet is a system to monitor the activity of influenza-like-illness (ILI) with the aid of volunteers via the internet. It has been operational in The Netherlands and Belgium (since 2003), Portugal (since 2005) and Italy (since 2008), and the current objective is to implement InfluenzaNet in more European countries.

In contrast with the traditional system of sentinel networks of mainly primary care physicians coordinated by the European Influenza Surveillance Scheme (EISS), InfluenzaNet obtains its data directly from the population. This creates a fast and flexible monitoring system whose uniformity allows for direct comparison of ILI rates between countries.

Any resident of a country where InfluenzaNet is implemented can participate by completing an online application form, which contains various medical, geographic and behavioural questions. Participants are reminded weekly to report any symptoms they have experienced since their last visit. The incidence of ILI is determined on the basis of a uniform case definition.

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Immune cells in the lungs during severe influenza infection

Immune cells in the lungs during severe influenza infection

Our study provides a detailed profile and kinetics of innate immune cells in the lungs during severe IAV infection, highlighting inflammatory monocytes as the major infiltrate and identifying a role for iNKT cells in control of these cells and lung immune-pathology.

Little is known of how a strong immune response in the lungs is regulated to minimize tissue injury during severe influenza A virus (IAV) infection. Here, using a model of lethal, high-pathogenicity IAV infection, we first show that Ly6ChiLy6G– inflammatory monocytes, and not neutrophils, are the main infiltrate in lungs of WT mice. Mice devoid of iNKT cells (Jα18−/− mice) have increased levels of inflammatory monocytes, which correlated with increased lung injury and mortality (but not viral load). Activation of iNKT cells correlated with reduction of MCP-1 levels and improved outcome. iNKT cells were able to selectively lyse infected, MCP-1-producing monocytes in vitro, in a CD1d-dependent process.

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March 5, 2012, 2:43 p.m.